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Comorbidities and Treatment Patterns Differ in Young Menwith Peyronie's Disease
Peris R. Castaneda, MD, Amy Zheng, MD, Samantha Freeman, MD, Alex Vanni, MD.
Lahey Hospital and Medical Center, Burlington, MA, USA.
Background: Peyronie's disease (PD) typically presents in the fifth decade of life, but also affects men in their 20s-30s. Young men with PD represent an understudied population. Nearly all studies of PD in young men focus on small cohorts (n < 100). We use a large multi-institutional database to explore the demographics, clinical characteristics, and treatment patterns in young men (18-30 years) with PD compared to men of typical PD age (50-60 years).
Methods: We queried the TrinetX database for men ages 18-30 (younger cohort) and men ages 50-60 (older cohort) with a diagnosis of PD. Demographics, comorbidities, and treatment patterns were compared and assessed for statistical significance (p<0.01).
Results: 90,040 men had PD (ICD-10 N48.6). Of these, 2,389 (3%) were ages 18-30 and 19,315 (22%) were 50-60. Demographics, comorbidities, and treatments are shown in Table 1. Young men were less likely to undergo procedures for PD (7% vs 16%; p<0.001). The most common procedure in young men was penile plication, versus injection in older men. Compared to young men who had no procedure, young men who had a procedure were more likely to be Caucasian (73% vs 60%; p=0.002), have Type II diabetes (6% vs 1%, P<0.001) and have chronic pain (18% vs 9%; p=0.002). There were no differences in age, Tadalafil use, or anxiety or depressive disorders between young men who had a procedure and young men who did not (P>0.01).
Conclusion: Young men with PD have significant differences in comorbidities and treatment patterns compared to men of typical PD age. Further studies are needed on determinants of treatment preferences and outcomes of PD in this special population.
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